Cell Biology and Microbiology: A Continuous Cross-Feeding

Country Focus Uk Cell Biology Microbiology Spectroscopy

Soil Biology and Microbiology

From the Department of Microbiology, Tumor and Cell Biology,

Hantavirus-infection can cause severe disease in humans, with up to 40% case fatalities. Presently, no therapeutics or prophylaxis against hantaviral illness exists. The mechanisms underlying the onset of symptoms and the following pathogenesis are not fully known. In vitro research conducted on mono-layered human cell cultures with cell line adapted hantaviruses provides important knowledge fo...

Department of Microbiology, Tumor and Cell Biology (mtc)

4 LIST OF PUBLICATIONS AND MANUSCRIPTS 5 LIST OF ABBREVIATIONS 7 INTRODUCTION 8 1. General introduction to cancer 8 2. Tumor suppressor genes 10 2.1 Knudson’s two-hit hypothesis 10 2.2 The tumor suppressor pRb 11 2.3 The tumor suppressor p53 11 2.4 Tumor suppressor genes on chromosome 3, especially on 3p21.3 13 2.5 Examples of chromosome 3p tumor suppressor genes 15 3. Epigenetics 17 3.1 CpG is...

Extracellular Chromatin Traps Interconnect Cell Biology, Microbiology, and Immunology

because the reaction pathway of this enzyme is understood in molecular detail. Leshner et al. (2012) provide an elegant illustration of PAD4’s potential to induce NETs. They demonstrate that overexpression of PAD4 in heterologous cells leads to chromatin decondensation and unfolding of NET-like chromatin. Induced PAD4 expression leads to histone deimination and the release of NET-like webs from...